Duke football takes the road for the first time of 2025, heading to New Orleans, Louisiana, to take on Tulane on Saturday, Sept. 13 (8 p.m. ET, ESPN2).

The Blue Devils will be looking to get back in the win column following a 45-19 Week 2 loss to Illinois, one marked by five Duke turnovers. They are up against a 2-0 Green Wave team coming off a 33-31 win over South Alabama.

The meeting will also mark a return to Yulman Stadium for Duke quarterback Darian Mensah , who transferred from Tulane to Duke in December 2024.

Duke is 3-2 overall against Tulane, winning the last three match-ups.

Here are picks, predictions and odds for Duke's Week 3 matchup at Tulane Stream Duke vs. Tulane on FUBO (free trial)

Duke vs Tulane odds, money line, over/under

Odds courtesy of BetMGM as of

See Full Page