When the No. 2 team in the country hosts an FCS program, it rarely ends well for the little guy.

That scenario should play out again on Saturday afternoon at Beaver Stadium.

Penn State (2-0) is a 48.5-point favorite over the Villanova Wildcats, who opened their season with a 24-17 victory over Colgate last Saturday. The PSU-Villanova betting line is posted on FanDuel.

James Franklin’s Nittany Lions opened their season with home wins over Nevada (46-11) and Florida International (34-0).

PSU and Villanova last played in 2021, with the Lions winning 38-17 in State College.

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