NFC West meets NFC South as the Arizona Cardinals host the Carolina Panthers in Week 2 NFL action. The Cardinals head into their home opener in the win column after kicking off their 2025 campaign with a 20-13 win against the New Orleans Saints. The Panthers, on the other hand, are in search of their first win of the season after falling 23-10 to the Jacksonville Jaguars in their season premier.

Kickoff from State Farm Stadium is set for 4:05 p.m. ET on CBS and Paramount+ . Arizona is a 6.5-point favorite in the latest Panthers vs. Cardinals odds from SportsLine consensus, while the over/under for total points scored is set at 44.5. The Cardinals are -299 money line favorites (risk $299 to win $100), while the Panthers are +240 underdogs. Before making any Cardinals vs. Panthers pic

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