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Ben Shapiro and Bill Maher sparred over morality and the Bible on "Real Time with Bill Maher: Overtime" Friday, and the conservative Orthodox Jewish commentator received an unexpected reaction from the liberal comedian’s Los Angeles audience.

Maher, the star of the anti-religion documentary "Religulous" and a well-known atheist, said the Bible contains "nonsense" and "wickedness."

"If God wrote the book, how could there be ‘things we don’t agree with?’ It’s got to be perfect because it’s written by you-know-who, or it’s just not perfect because it was written by people, obviously, and it’s full of nonsense and wickedness," Maher said, drawing laughter from the audience.

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