GLP-1 agonists —so-called “ wonder drugs” like Ozempic or Wegovy that help individuals lower blood sugar levels and lose weight, among other things—yield significant results for some patients, but not all. People’s motivations to overeat may play a role in this, according to a new study.

To investigate why some people don’t benefit from GLP-1 agonists as much as others, researchers observed 92 participants with type 2 diabetes in Japan during their first year of taking GLP-1 drugs. Their results , published today in Frontiers in Clinical Diabetes and Healthcare, suggest that people who overeat due to external reasons—such as the sight or smell of delicious food—had greater chances of responding well to the drugs in the long term than people who overeat for emotional reasons.

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