Syracuse Orange quarterback Steve Angeli (9) throws against the UConn Huskies during the second half at JMA Wireless Dome in Syracuse, New York.

The Syracuse Orange (2-1) visit the Clemson Tigers (1-2) Saturday at Memorial Stadium in Clemson, South Carolina. Kickoff is scheduled for noon ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA football odds around the Syracuse vs. Clemson odds and make our expert college football picks and predictions for the best bets.

Syracuse has won back-to-back games after dominating the Colgate Raiders 66-24 last Saturday and covering as a 36.5-point home favorite. QB Steve Angeli went 23 of 31 for 382 yards and 5 touchdowns while adding a TD on the ground. WR Darrell Gill Jr. had 6 receptions for 152 yards and 2 TDs.

Clemson has dropped 2 of its first 3 games after losing 24-21 to the Georgia Tech Yellow Jackets last week as a 3-point road favorite. QB Cade Klubnik went 15 of 26 for 207 yards with a TD and an interception while rushing for 62 yards and a TD. WR Bryant Wesco Jr. had 7 receptions for 126 yards and a TD in the losing effort.

Clemson leads the all-time series 10-2, including a 31-14 win in their last meeting in 2023 in Syracuse, New York.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Syracuse at Clemson odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 4:02 p.m. ET.

  • Moneyline (ML): Syracuse +550 (bet $100 to win $550) | Clemson -800 (bet $800 to win $100)
  • Against the spread (ATS): Syracuse +17 (-110) | Clemson -17 (-110)
  • Over/Under (O/U): 54.5 (O: -110 | U: -110)

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Syracuse at Clemson picks and predictions

Prediction

Clemson 31, Syracuse 19

Moneyline

PASS.

There is no value on Clemson (-800), which has been dominant at home in recent years, to win Saturday

Against the spread

BET SYRACUSE +17 (-110).

Until proven otherwise, Clemson, which dropped out of the Top 25 this week, has not shown anything this season to be confident backing them. They have failed to cover in each of their games this season while scoring 27 or fewer points in each game.

Syracuse has scored at least 26 points in all 3 of its games this season and has pushed or covered in back-to-back weeks.

With each team showing its early-season form, a 3-score spread is too large for the favorites.

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Over/Under

BET UNDER 54.5 (-110).

Clemson's offense has not shown much upside early on this season, hitting the Under in each game this season and hitting the Under in 7 of its last 9 games dating back to last season. It has scored 21 or fewer points in 2 of its 3 games while allowing 24 or fewer points in each of its games.

Syracuse will not have the offensive success it showed last week against a tougher Tigers' defense. The Orange have scored 27 or fewer points in 2 of their 3 games while allowing 24 or fewer points in 2 of their 3 games.

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This article originally appeared on Sportsbook Wire: Syracuse Orange at Clemson Tigers odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

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