Today’s MLB Betting Trends:

The following is a collection of analytical data, betting systems and strength ratings featured on VSiN and qualified for the MLB games of Sunday, September 21, 2025. This report is meant to emulate the process that Steve Makinen and other members of the VSiN Analytics team undergo when handicapping each day’s MLB board.

AJ’s Angles

These are the top trends and systems for today’s games, handpicked by VSiN Analyst AJ Makinen.

Trend: CLEVELAND has dominated Minnesota in recent seasons of head-to-head play, going 36-13 (73.5%, +25.11 units).

– The R.O.I. on this trend is 51.2%

Trend Match (PLAY): CLEVELAND (-138 at MIN)

Trend: Sean Manaea is 13-1 (+10.94 units) as a HOME favorite of -180 or more in L6 seasons

Trend Match (PLAY): NY METS (-281 vs WSH)

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