Nick Bosa suffered a knee injury in the first quarter of the 49ers’ game against the Cardinals on Sunday at Levi’s Stadium.

Bosa, 27, went down on the final play of Arizona’s second drive of the game after being double-teamed by two Cardinals offensive linemen.

He limped to the sideline, threw his helmet and lay down before trainers began evaluating his right leg. He then walked to the blue medical tent on the sideline for further examination, looking to the stands and giving a speculative thumbs-down gesture. Bosa was initially listed as questionable to return, then ruled out at halftime.

Bosa opened the season with a sack in each of the 49ers’ first two wins, the first time that’s happened since he started his 2022 NFL Defensive Player of the Year season. His sack in the season opener

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