SANTA CLARA, Calif. -- San Francisco 49ers defensive end Nick Bosa will not return Sunday's game against the Arizona Cardinals after suffering a knee injury late in the first quarter.

On the play, Bosa was rushing Cardinals quarterback Kyler Murray from the left side and engaged with left tackle Kelvin Beachum when Cardinals guard Evan Brown came over for the double team.

Bosa's knee appeared to bend awkwardly as he went to the ground and Murray's pass fell incomplete. Bosa walked slowly to the sideline, where the Niners' training staff began working on him as he laid on his back.

After a few moments, Bosa walked to the blue medical tent, where he remained for about five minutes before emerging. He spent the next couple of minutes doing some stretching and high knees but eve

See Full Page