James Conner suffered a scary-looking injury during the third quarter of the Cardinals’ game against the 49ers.

The running back was hit low on a rushing attempt when his ankle got trapped under him and appeared to bend in an awkward position as he was brought down by a 49ers player, immediately causing an obvious amount of pain for Conner. 3

OMG James Connor’s knee went the other way

Prayers up, this looked like an ACL or MCL tear 😢 #AZvsSF pic.twitter.com/O9QQ46KrkU — Benchwarmer Sports (@bdubsports_) September 21, 2025

Conner grabbed for his lower right leg and after the Cardinals’ medical staff came out to check on him, he was carted off the field as his teammates came onto the field to show their support and concern for their injured teammate.

Arizona quickly ruled Co

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