The Los Angeles Rams (2-1) are hosting the Indianpolis Colts (3-0) for Week 4 of the NFL season, and the opening odds, at least at FanDuel, favor the Colts by 3.5 points, and that’s meaningful as the Rams are home for this matchup, but they are the underdogs. That’s a little atypical at the NFL level where home teams are generally favored.

The over/under point total is is 47.5 as the oddsmakers must expect Matthew Stafford and Daniel Jones to put up some numbers on Sunday.

The last time these two teams faced-off, L.A. won in overtime as Puka Nacua arrived at the NFL level with 9 catches for 163 yards and a walk-off touchdown. But that was a couple seasons ago, so what happened then, may not really hae any impact on how this matchup will go in ’25.

The Colts are coming into this game as

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