The Arizona Cardinals suffered a heartbreaking 16-15 loss to the San Francisco 49ers on Sunday, but the scoreboard wasn’t the only gut punch. Veteran running back James Conner, the heart of Arizona’s ground game, was carted off in the third quarter with a right ankle injury that multiple reports suggest could end his season.

Conner went down after a 9-yard run, his longest carry since Week 1, with just over 12 minutes remaining in the third. Trainers rushed to his side as players from both teams took a knee. The entire Cardinals sideline walked onto the field, underscoring just how significant his presence is to the locker room. He left the field on a cart after being helped onto it by teammates, waving to the crowd but visibly in pain.

According to ESPN’s Josh Weinfuss, Arizona i

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