Those looking to make Week 5 college football picks will have no shortage of quality games to choose from, including a pair of ranked matchups in both the Big Ten and SEC. With the former, Penn State vs. Oregon sees a pair of top-10 ranked squads facing off, with the Nittany Lions favored by 3.5 points in the latest Week 5 college football odds. Also USC vs. Illinois (+6.5) will see the Illini looking to bounce back after a 53-point beatdown by Indiana last Saturday.

In the SEC, Week 5 college football bets figure to center on LSU vs. Ole Miss (-2) and Alabama vs. Georgia (-3). Either of these could be potential previews of the SEC Championship Game, if not the College Football Playoff. This week's schedule also features several larger college football spreads, if one still yearns for tho

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