Those looking to make Week 5 college football picks will have no shortage of quality games to choose from, including a pair of ranked matchups in both the Big Ten and SEC. With the former, Penn State vs. Oregon sees a pair of top-10 ranked squads facing off, with the Nittany Lions favored by 3.5 points in the latest Week 5 college football odds. Also USC vs. Illinois (+6.5) will see the Illini looking to bounce back after a 53-point loss to Indiana last Saturday.

In the SEC, Week 5 college football bets figure to center on LSU vs. Ole Miss (-1.5) and Alabama vs. Georgia (-3). Either of these could be potential previews of the SEC Championship Game and/or a the College Football Playoff matchup. This week's schedule also features several larger college football spreads, including Oklahoma S

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