Mike's Week 5 college football betting picks against the spread for Thursday, September 25, and Friday, September 26, 2025. Free CFB betting predictions, odds analysis, and ATS picks from RotoBaller.

Week 4 of the 2025 college football season brought some more upsets. Who would have guessed that Clemson and Florida would both be 1-3 and that Florida State would have more wins than they did in 2024?

No FCS teams collected scalps this week, and time is running out for them to collect more. There are only two FBS teams playing FCS teams this week. We're almost done with that madness.

We have another loaded weekend with 53 total games. We have one on Thursday and three more on Friday. All of those are FBS vs. FBS matchups this week. We'll also take a look back at my record for Week 4. Feat

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