Week 4 of the 2025 NFL season will kickoff with a Thursday Night Football matchup between the Seattle Seahawks (2-1) and the Arizona Cardinals (2-1).

The Seahawks lead the all-time series between these teams, 29-22-1, and have won eight of their nine most-recent meetings. They last faced off in December 2024, with the Seahawks winning on the road in Arizona, 30-18.

There aren’t many former Eagles in Thursday’s matchup, but DE Josh Sweat is out there for the Cardinals defense, and CB Josh Jobe has been having a really good season for Seattle.

Here’s everything you need to know about tonight’s game.

Seattle Seahawks at Arizona Cardinals

TV Schedule

Game time: 8:15 PM EST

Channel: Prime Video

Date: Thursday, September 25, 2025

Location: State Farm Stadium | Glendale, AZ

Announcers:

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