A Big Ten battle is set for Saturday as the No. 3 Penn State Nittany Lions host the No. 6 Oregon Ducks (4-0) in 2025 college football Week 5. This is the first meeting between these teams since the Big Ten title game last season, which the Ducks won 45-37. Oregon is already 1-0 in conference play in 2025 after defeating Northwestern in 34-14 in Week 2, and Penn State will be playing its first game against a Big Ten opponent following a Week 4 bye.

Kickoff from Beaver Stadium is set for 7:30 p.m. ET. The Nittany Lions are 3.5-point favorites in the latest Oregon vs. Penn State odds, and the over/under for total points scored is 52.5. Penn State is a -175 money line favorite (risk $175 to win $100) and Oregon is a +146 underdog (risk $100 to win $146). Before making any Penn State vs. O

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