Iowa State Cyclones' running back Carson Hansen (26) runs with the ball after handed off from Iowa State Cyclones' quarterback Rocco Becht (3) against South Dakota during the first quarter in the home game opening at Jack Trice Stadium in Ames, Iowa.

The Arizona Wildcats (3-0, 0-0 Big 12) and No. 13 Iowa State Cyclones (4-0, 1-0) meet in a Week 5 Big 12 clash Saturday. Kickoff from Jack Trice Stadium in Ames, Iowa, is set for 7 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA football odds around the Arizona vs. Iowa State odds and make our expert college football picks and predictions for the best bets.

Arizona took down the Kansas State Wildcats 23-17 Sept. 12 in Week 3 action, following a Week 4 bye. It covered as a 1.5-point home underdog. Prior to that, Arizona dominated Weber State (48-3 Sept. 6) and Hawaii (40-6 Aug. 30), combining for an 88-9 margin in its first 2 games of the season. Arizona is 3-0 against the spread (ATS). QB Noah Fifita has been the main threat for the Wildcats, throwing for 6 touchdowns and 712 yards through 3 games.

Iowa State edged the Arkansas State Red Wolves 24-16 on the road in Week 3, failing to cover as a 21-point favorite. The Cyclones defeated the Iowa Hawkeyes 16-13 at home the week prior. Through 4 games, Iowa State is 2-1-1 ATS, going 1-0-1 ATS at home. QB Rocco Becht, widely expected to be among the best quarterbacks in the Big 12, has thrown for 860 yards and 7 touchdowns through 4 games.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Arizona at Iowa State odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 5:20 p.m. ET.

  • Moneyline (ML): Arizona +180 (bet $100 to win $180) | Iowa State -220 (bet $220 to win $100)
  • Against the spread: Arizona +5.5 (-110) | Iowa State -5.5 (-110)
  • Over/Under (O/U): 48.5 (O: -110 | U: -110)

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Arizona at Iowa State picks and predictions

Prediction

Iowa State 24, Arizona 23

Moneyline

PASS.

While Arizona (+180) might pull off the upset, it is better played on the spread. Iowa State (-220) is far too expensive to consider here.

Against the spread

BET ARIZONA +5.5 (-110).

The Wildcats have an explosive running game, and the Cyclones may struggle to shut that down. Iowa State ranks 52nd in the country, allowing 135.3 yards per game on the ground. Arizona ranks 40th in rushing play percentage and averages 208.5 yards per game, so it should be able to keep moving the chains on the ground.

Iowa State has struggled to score and separate itself from quality opponents. It beat Kansas State by 3 and Iowa by 3. Against Arkansas State, it won by just 8 points despite being favored by 21. It is 4-0, but its lone win by more than a touchdown was as a 16.5-point favorite (55-7 vs. South Dakota Aug. 30).

Expect this game to be a close one, and take ARIZONA +5.5 (-110).

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Over/Under

BET UNDER 48.5 (-110).

Both teams have had impressive defensive showings throughout the early season. The Cyclones have yet to allow more than 21 points and are 1-3 O/U on the year.

The Wildcats are 0-3 O/U. They allowed just 9 points over their first 2 games and then 17 against Kansas State. Considering those trends, expect a low-scoring battle, and take UNDER 48.5 (-110).

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This article originally appeared on Sportsbook Wire: Arizona Wildcats at Iowa State Cyclones odds, picks and predictions

Reporting by Nathan Beighle, Sportsbook Wire / Sportsbook Wire

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