Four people have been taken to hospital after a car left the road and crashed in Perth’s south in the early hours of Saturday morning.

Police say a grey Mercedes-Benz sedan was travelling north on Cockburn Road near the intersection of Bull Road in North Coogee about 3.50am on Saturday when it rolled and hit a tree next to the road.

The accident left the 24-year-old male driver with serious injuries and two female passengers, aged 18 and 19, with critical injuries, a police spokeswoman said.

They were all taken to Royal Perth Hospital by ambulance for treatment.

A third passenger, a 21-year-old man, only suffered minor injuries and was treated in Fiona Stanley Hospital.

Police are appealing for anyone who witnessed the crash, or saw the vehicle travelling in the area prior to the i

See Full Page