Apr 26, 2025; University Park, PA, USA; Penn State Nittany Lions running back Nicholas Singleton (10) runs a play during a warm up prior to the Blue White spring game at Beaver Stadium. Mandatory Credit: Matthew O'Haren-Imagn Images

Week 5 is punctuated with a huge Big 10 battle on Saturday night when the Oregon Ducks visit the Penn State Nittany Lions. It will be a daunting task for the Ducks as they venture into the White Out at Happy Valley. It is one of the most intimidating places to play in all of college football and it highlights a great day of football.

The Nittany Lions come into the game 3-0 and have been led by Drew Allar, who has thrown for 626 yards and two touchdowns. Kaytron Allen has led the team on the ground with 273 yards and three touchdowns Nicholas Singleton has been good also, as he has gone for 179 yards and five touchdowns.

The Ducks also haven't been tested, but have at least played a Power Four school. They whipped Oklahoma State 69-3 and have, overall, looked dominant in their first four games.

Stream Penn State vs. Oregon

Dante Moore has been great to start the season for the Ducks. He has thrown for 962 yards and 11 touchdowns. Three different receivers have at least 10 receptions for Oregon. Dakorien Moore, Malik Benson and Gary Bryant Jr. have 12, 14 and 10 catches, respectively.

If you're looking to get back in the swing of football season and need some betting advice for Saturday's matchup in Happy Valley, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Penn State vs. Oregon game odds:

All college football odds via BetMGM

  • Spread: Penn State -3.5 (-110), Oregon +14 (-110)
  • Money Line: Penn State -175, Oregon +145
  • Over-Under: Over 52.5 (-110), Under 52.5 (-110)

Penn State vs. Oregon prediction, pick:

This is the ultimate prove-it game for Penn State. They have been one of the best teams in the Big Ten, but haven't been able to beat the top teams. Ohio State, Michigan, and now Oregon. They have struggled, but this is the time to break that stigma. They are at home, it's a white-out game, and they have the experience to win this game. The Ducks, though, have a ton of talent and are scoring a ton of points. They haven't played anybody good, though, and the Nittany Lions will do enough to win the game.

Prediction: Penn State 27, Oregon 20

Best Bet: Penn State -3.5, Under 52.5

Penn State vs. Oregon channel, start time, streaming:

Time: 7:30 p.m. ET

TV Channel: NBC

Live Stream: NBC App

Get more betting analysis and predictions at Sportsbook Wire.

Contact/Follow @College_Wire on X and @College_Wires on Threads. Like our page on Facebook to follow ongoing coverage of college sports news, notes, and opinions.

This article originally appeared on College Sports Wire: Penn State vs. Oregon: Week 5 College Football Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

USA TODAY Network via Reuters Connect