Week 5 of the NFL season opens Thursday night in Southern California with first place on the line in the NFC West when the San Francisco 49ers (3-1) take the field at SoFi Stadium against the Los Angeles Rams (3-1).

The Niners laundry list of injuries finally caught up with them this past weekend as Trevor Lawrence and the Jaguars handed Kyle Shanahan’s squad their first loss. Jacksonville jumped out to a 17-6 lead at halftime and the 49ers really never threatened a comeback in the second half.

As mentioned, San Francisco continues to be one of the more banged up teams in the league. Brock Purdy’s availability is again a question mark this week as is that of as many as five wide receivers and a couple of cornerbacks. Already sidelined for the season is Nick Bosa .

The Rams impro

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