The Week 5 NFL schedule is the first with byes, meaning there are fewer contests to make Week 5 NFL bets on than before. That also means you can devote more time, energy and resources to these matchups, which include a number of inter-conference affairs. Jets vs. Cowboys (-2.5), Broncos vs. Eagles (-4.5), Bengals vs. Lions (-8.5) and Chargers vs. Commanders (+3) are some of the AFC vs. NFC games to place Week 5 NFL predictions on.

There is just one divisional game on Sunday and it sees the Bills hosting the Patriots (+8.5) on Sunday Night Football. Some may prefer making Week 5 NFL picks on common matchups like this one, or the rarer non-conference contests could drum up more interest with NFL betting. All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced compute

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