Matt's must-start fantasy football waiver wire defenses (D/ST) to stream and start for Week 5 of the 2025 season. His fantasy defense start 'em, sit 'em picks.

The 2025 fantasy football season is heading into Week 5, which means the introduction of bye weeks for the first time. Looking for help at the D/ST spot? Get these high-impact defenses on your roster now! RotoBaller analyst Matt Donnelly drops his fantasy football must-start defenses (D/ST) for Week 5 of the 2025 season.

With bye weeks now hitting, decisions are coming at a furious pace. We are here to help with your Week 5 D/ST streamers, to give you the tools needed to set those winning lineups.

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