Fantasy football start 'em, sit 'em lineups advice for 49ers vs. Rams on Thursday Night Football in Week 5 (2025). NFL matchups analysis and TNF starts/sits.

If you didn't get your fill of NFC West football last Thursday night, I've got some good news for you! In Week 5, we get the other two teams in the division as the San Francisco 49ers travel to face the Los Angeles Rams. For fantasy football, some of the game's elite performers are suiting up in this contest, but there are also plenty of injury concerns to worry about for one side.

No matter what happens, this game features a matchup of the potential top running back in the league and the top wide receiver in the league. But with so many question marks due to potential injuries, it will be all the more important to make sure you are

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