The Los Angeles Rams will be facing a severely shorthanded San Francisco 49ers team on Thursday night. Ahead of this marquee game between NFC West rivals, the 49ers ruled out several key starters.

They will not have Brock Purdy, Ricky Pearsall or Jauan Jennings, as all three have been ruled out for Week 5. Wide receiver Jordan Watkins and defensive end Robert Beal have also been ruled out, according to Matt Maiocco of NBC Sports Bay Area.

This will be the third game missed for Purdy in 2025; he suffered a toe injury in Week 1, missed Weeks 2 and 3 but returned last week against the Jacksonville Jaguars. He didn’t come out of that game clean and will now be sidelined once again.

In Purdy’s place, the 49ers will turn to Mac Jones, who said this week that the Rams have the best defense in

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