LOS ANGELES -- The San Francisco 49ers ' offense will be even more short-handed than it's been in the season's opening month when it takes on the Los Angeles Rams on Thursday night.

On Wednesday, the Niners ruled out quarterback Brock Purdy (toe) and receivers Jauan Jennings (ribs, ankle), Ricky Pearsall (right knee) and Jordan Watkins (calf).

Those injuries are in addition to a list of those already missing that includes tight end George Kittle (hamstring) and wideout Brandon Aiyuk (knee).

On Tuesday, Purdy offered some optimism that he might still be able to play despite the toe soreness that began plaguing him Sunday night after the Niners lost to the Jaguars . But he also cautioned that the short time from Sunday's game to Thursday night would make it difficult.

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