The San Francisco 49ers are set to face the Los Angeles Rams on Thursday Night Football for their third divisional game in five weeks.

It’s one where the 49ers are severely injured, with Brock Purdy, Ricky Pearsall, and Jauan Jennings being ruled out in addition to stars like George Kittle and Nick Bosa not playing.

So, the 49ers will trot out Mac Jones and five receivers who didn’t catch a pass for the team in 2024 as they look to upset the 3-1 Rams on the road. How can they make that possible?

Here are three keys to a 49ers win over the Rams on Thursday.

Deliver on third downs defensively

The Rams have been a quality football team so far this season. But, they definitely have flaws, with third-down conversions being near or at the top of the list over the past two weeks.

In last we

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