Week 5 of NFL action begins tonight, with the Los Angeles Rams hosting the San Francisco 49ers for another classic NFC West showdown. The 49ers will once again be without quarterback Brock Purdy, who’s been dealing with left shoulder and toe injuries, the latter of which has him on a week-to-week timeline at the moment.

That means for the third game, it’s the Mac Jones show at quarterback, though we’re likely to see a very healthy dose of running back Christian McCaffrey. Los Angeles and San Francisco are both 3-1, with the Niners atop the division, and the Rams listed third, and the Seattle Seahawks nesting between the two.

Wide receiver Puka Nacua is on an absolute tear in 2025, leading the league in targets (50; 42 receptions) and also yards (503).

Here’s your open thread for tonight

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