There’s a big NFC game to kick off Week 5 of the 2025 NFL season. The Los Angeles Rams are off to a hot start, racking up a 3-1 record. They’d be undefeated had they not blown a significant lead against the Philadelphia Eagles a couple weeks back. Speaking of backs, Matthew Stafford looks like himself despite battling a back injury for most of the offseason. Stafford has an arsenal of weapons at his disposal and a young, aggressive defense to help give him the ball back.

Things aren’t quite as optimistic for the San Francisco 49ers, despite the fact that they, too, are 3-1 to start the season. That largely has to do with one thing: injuries. The following players won’t play for the 49ers on Thursday: • QB Brock Purdy • WR Jauan Jennings • WR Ricky Persall • TE George Kittle • ED

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