Las Vegas Raiders at Indianapolis Colts odds, picks and predictions

Indianapolis Colts quarterback Daniel Jones (17) sets to pass during the first half against the Los Angeles Rams at SoFi Stadium in Inglewood, California.

The Las Vegas Raiders (1-3) and Indianapolis Colts (3-1) clash Sunday in Week 5. Kickoff from Lucas Oil Stadium in Indianapolis is set for 1 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Raiders vs. Colts odds and make our expert NFL picks and predictions for the best bets.

The Raiders have lost 3 straight after a season-opening win at the New England Patriots. They are coming off a 25-24 loss as a 1.5-point home favorite against the Chicago Bears in Week 4 as the Over (48) cashed. RB Ashton Jeanty recorded his first career 3-touchdown game, rushing for 138 yards and a score while adding 17 receiving yards and catching 2 touchdown passes. Las Vegas is 1-3 against the spread (ATS).

The Colts lost 27-20 at the LA Rams in Week 4, their first defeat of the season. They failed to cover as 3.5-point underdogs and the Under (50) hit. QB Daniel Jones had 262 passing yards, 1 TD and 2 INTs. Indianapolis is 3-1 ATS.

The Colts won the last meeting 23-20 in 2023, evening the all-time series at 11-11.

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Raiders at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 2:25 p.m. ET.

Moneyline (ML): Raiders +260 (bet $100 to win $260) | Colts -325 (bet $325 to win $100)
Against the spread: Raiders +7 (-115) | Colts -7 (-105)
Over/Under (O/U): 48 (O: -110 | U: -110)

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Raiders at Colts key injuries

Raiders

TE Brock Bowers (knee) questionable
CB Eric Stokes (knee) questionable

Colts

CB Kenny Moore II (Achilles) out
WR Alec Pierce (concussion) out

Raiders at Colts picks and predictions

Prediction

Colts 27, Raiders 17

Moneyline

PASS.

Avoid this play. The Colts (-325) are far too expensive of a favorite, while the Raiders (+260) haven't shown enough to suggest they can pull off the upset.

Against the spread

BET COLTS -7 (-105).

The Colts offense has been efficient this season, especially at home. It has averaged 31 points through 2 home games and is 2-0 ATS as a favorite and 2-0 ATS at home this season.

The Raiders are 0-3 ATS in losses and 1-2 ATS as an underdog. Their defense has allowed an average of 33 points over their last 2 games, while their offense has yet to score more than 24 in a single contest.

Considering those trends, take COLTS -7 (-105).

Over/Under

BET UNDER 48 (-110).

Both teams are 2-2 O/U entering Sunday.

The Raiders have allowed more than 25 points just once this season and are 1-2 O/U as an underdog. They are averaging 15.5 points per game as an underdog of 3 or more points.

The Colts are allowing just 18 points per game at home this season and are 0-2 O/U when the total closes above 43. Back UNDER 48 (-110).

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This article originally appeared on Sportsbook Wire: Las Vegas Raiders at Indianapolis Colts odds, picks and predictions

Reporting by Nathan Beighle, Sportsbook Wire / Sportsbook Wire

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