The first month of the 2025 regular season is in the books. As the calendar turns to October and the leaves begin to change, the action across the NFL is ramping up in a big way. In Week 5, there are a number of notable matchups, including the first game of this year's London slate, Denver visiting Philadelphia and an AFC East clash between the Patriots and Bills on Sunday night.

As we do every week throughout the season, we've collected all of the best picks and gambling content from CBS Sports and SportsLine and put them in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Rea

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