The Arizona Cardinals continue their 2025 NFL regular season schedule with an NFL Week 5 game against the Tennessee Titans today.

The Cardinals are coming off a 23-20 loss against the Seattle Seahawks in their NFL Week 4 game.

The Titans lost to the Houston Texans in the fourth week of the season, 26-0.

This is the first game between Arizona and Tennessee since 2021, when the Cardinals defeated the Titans in Nashville, 38-13.

Follow our live updates of the game, which is being played at the Cardinals' State Farm Stadium in Glendale, Arizona, for the latest score, news, notes and analysis of the Week 5 NFL game on Oct. 5. Expert MLB daily picks: Unique MLB betting insights only at USA TODAY Watch Titans at Cardinals with FUBO (free trial)

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