The NFL Week 5 slate of Sunday games will cap off with a Sunday Night Football matchup between the New England Patriots (2-2) on the road against the Buffalo Bills (4-0).

The Patriots lead the all-time regular season series between these divisional rivals, 78-50-1, and the home team has won the past five meetings. They last faced off back in January 2025, with the Patriots winning at home, 23-16.

Here’s everything you need to know about tonight’s game.

New England Patriots vs. Buffalo Bills

TV Schedule

Game time: 8:20 PM EST

Channel: NBC

Date: Sunday, October 5, 2025

Location: Highmark Stadium | Buffalo, NY

Announcers: Mike Tirico, Cris Collinsworth, Melissa Stark

Online Streaming

Peacock | FuboTV

Odds via FanDuel

Odds via FanDuel

New England Patriots: +7.5 (+330)

Buffalo Bi

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