STOCKHOLM (AP) — Mary E. Brunkow, Fred Ramsdell and Dr. Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance.

Brunkow, 64, is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell, 64, is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi, 74, is a distinguished professor at the Immunology Frontier Research Center at Osaka University in Japan.

Brunkow got the news of her prize from an AP photographer who came to her home in the early hours of the morning.

She said she had ignored the earlier call from the Nobel committee. “My phone rang and I saw a number from Sweden and thought: ‘That’s just, that’s spam of some sort.'”

“When I told Mary she won, she said, ‘don’t be

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