Nobel Prize In Physiology Or Medicine 2025 Goes To Breakthrough That Helped Uncover The Cause Of Autoimmune Diseases

The winners of the 2025 Nobel Prize in Physiology or Medicine are Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance". The prize is worth 11 million Swedish kronor (around $1,170,000 USD at the time of publishing), which will be shared equally between the winners. The rest of this article is behind a paywall. Please sign in or subscribe to access the full content.

Our body has a system known as central tolerance, which works in sites like the thymus and the bone marrow to eliminate T and B lymphocytes that have become auto- or self-reactive – this means that these immune cells can attack our own body. But central tolerance is not perfect. Some self-reactive cells can escape into the circulation, and there is a danger tha