As the 2025 NFL season rolls into Week 6, fantasy football managers face the weekly challenge of setting their ideal running back lineups. With key contributors from the Minnesota Vikings and Houston Texans not seeing action, roster depth and waiver-wire strategy become critical. The running back position remains the heartbeat of most fantasy squads. They are capable of swinging weekly matchups with multi-touchdown performances or PPR-heavy outings. This week’s rankings spotlight the elite tier, with players like Bijan Robinson , Jahmyr Gibbs , and De’Von Achane, while also identifying sleepers who could deliver unexpected value.

Key insights

The Week 6 slate brings challenges with both Minnesota and Houston on bye. This takes productive fantasy football options Jordan Mason, Nick

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