A medical emergency helicopter has crashed on a busy stretch of Highway 50 in the Californian city of Sacramento, injuring three, although there was no patient aboard.

Survivors were taken to hospital to be treated, Sacramento Mayor Kevin McCarty said in a post on X on Monday night after the aircraft went down near the city's 59th Street on the eastbound side of the highway.

"We are in the process of determining the details of this situation, as well as the condition of the crew involved, who were all taken to area hospitals," operator REACH told Reuters in an email.

The company provides services for the critically ill and injured across the western United States, its website shows.

The cause of the crash was being investigated, said CBS News, which initially reported the incident.

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