Seattle Mariners catcher Cal Raleigh (29) celebrates hitting a home run in the ninth inning against the Detroit Tigers during Game 3 of the ALDS in the 2025 MLB Playoffs at Comerica Park in Detroit, Michigan.

The Seattle Mariners and Detroit Tigers meet for Game 4 of their best-of-5 American League Division Series Wednesday at Comerica Park in Detroit, Michigan. The Mariners lead the series 2-1. First pitch is scheduled for 3:08 p.m. ET (FS1). Let's analyze BetMGM Sportsbook's MLB odds around the Mariners vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Regular-season series: Mariners won 4-2

Seattle beat Detroit 8-4 in Game 3 Tuesday, cashing as a -131 road favorite with the Over (7.5) hitting.

With the series tied 1-1, the Mariners built a 4-0 lead heading into the bottom of the fourth inning. The Tigers scored once in the fifth, but Seattle answered with 4 unanswered runs to take an 8-1 lead before Detroit added 3 in the ninth to make the final score appear closer than it really was.

C Cal Raleigh went 2-for-4 with a homer, a walk and 3 RBIs, while SS J.P. Crawford went 2-for-2 with a homer, a walk, 2 runs scored and 2 RBIs. 3B Eugenio Suarez also added a solo homer in the victory.

Detroit managed 7 hits in Game 3, with 2B Gleyber Torres providing the only multi-hit performance for the home side, including a double. 1B Spencer Torkelson went 1-for-4 with a double, a run scored and 2 RBIs. SP Jack Flaherty lasted just 3 1/3 innings, allowing 4 runs (3 earned) on 4 hits and 3 walks in the loss.

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Mariners at Tigers projected starters

RHP Bryce Miller vs. RHP Casey Mize

Miller (4-6, 5.68 ERA) made 18 regular-season starts. He posted a 1.41 WHIP, 3.4 BB/9 and 7.4 K/9 in 90 1/3 innings.

  • Last start: Loss, 4 IP, 4 ER, 5 H (2 HR), 2 BB, 2 K in 6-1 home setback vs. LA Dodgers Sept. 28
  • 2025 road stats: 2-3, 5.56 ERA (45 1/3 IP, 28 ER), 1.43 WHIP, 7 HR, 6.6 K/9 in 9 starts
  • Career vs. Tigers: 2-0, 0.00 ERA (19 IP), 0.58 WHIP, 10 H, 1 BB, 15 K in 3 starts
  • Has never played in postseason

Mize (14-6, 3.87 ERA) made 28 regular-season starts. He posted a 1.27 WHIP, 2.2 BB/9 and 8.4 K/9 in 149 innings.

  • Last start: No-decision, 3 IP, 1 ER, 1 H (solo HR), 2 BB, 1 K in 6-1 defeat at Cleveland Guardians in Game 2 of AL Wild Card Series Oct. 1; his first career postseason start
  • 2025 home stats: 8-2, 3.68 ERA (73 1/3 IP, 30 ER), 1.21 WHIP, 11 HR, 7.4 K/9 in 14 starts
  • Career vs. Mariners: 2-1, 4.03 ERA (22 1/3 IP, 10 ER), 1.03 WHIP, 14 H, 3 HR, 9 BB, 23 K in 4 starts

Mariners at Tigers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:33 a.m. ET.

  • Moneyline (ML): Mariners -110 (bet $110 to win $100) | Tigers -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Mariners -1.5 (+155) | Tigers +1.5 (-185)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Mariners at Tigers picks and predictions

Prediction

Tigers 5, Mariners 3

Moneyline

The TIGERS (-110) are a decent play with their backs against the wall, as Mize looks to get the job done and force a decisive Game 5.

After going 3-1 in its first 4 postseason games, Detroit has dropped its past 2 outings, including Tuesday’s disappointing Game 3 loss on its home field. However, the pitching matchup favors Detroit, with Mize facing the erratic Miller.

Run line/Against the spread

The Tigers +1.5 (-185) will cost you almost twice your potential return, which is too much risk for too little reward if you’re looking for insurance.

The Tigers allowed 8 runs, their most since Sept. 19, but you can expect Detroit to perform much better with its season on the line.

PASS.

Over/Under

UNDER 8.5 (-115) is the lean, but go with a half-unit play at most.

We saw the Over hit in Game 3, with the Mariners taking care of it on their own. However, it was the first Over after 2 straight Unders in Seattle. In Game 4, runs should be at a premium -- at least for Seattle -- as Mize has been fairly effective this season, especially at home. With the season on the line, lean low.

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This article originally appeared on Sportsbook Wire: Seattle Mariners at Detroit Tigers odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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