We are five full weeks into the 2025 NFL season, and with that, you are three weeks into your fantasy football season. Injuries have ravaged the fantasy football landscape so far, but you can catch back up to your leaguemates – or stay ahead of them – with these Week 6 waiver wire pickups.

The depth of your fantasy football roster is already being tested, as this week alone we saw rookie running back Omarion Hampton get placed on injured reserve, and players like Brock Bowers and Terry McLaurin continue to miss time.

The following list includes players (except one) that are rostered on fewer than 50 percent of all ESPN rosters making the chances you can pick them up pretty high. Heading into Week 6, try your best to button up the edges of your roster as you look to start the season s

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