Week 5 of the NFL season was a wild one, with crazy finishes and blown leads all over the league. Some of them came as a surprise, while others were just rhetorical latest episodes in futility for some of the NFL's troubled franchises .

Who came out on the wrong end of Week 5? Let's take a look at the biggest losers of the weekend.

Cardinals suffer one of the worst losses in recent memory

The 2025 Arizona Cardinals are no stranger to confusing, heartbreaking losses. In fact, Jonathan Gannon 's group has already suffered a pair of them against divisional opponents. After squandering a chance to beat the 49ers on the road, the Cardinals lost a chance to complete a comeback against the Seahawks, losing both games on last-second field goals.

With a 21-6 lead over the winless Tennessee

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