Kyler Murray's foot injury appears to be a bigger issue than previously thought.

The Arizona Cardinals quarterback briefly exited because of the injury in a 22-21 Week 5 loss to the Tennessee Titans but returned to the game. However, Pro Football Talk's Josh Alper reported Murray missed a second straight practice on Thursday.

On Wednesday, Cardinals head coach Jonathan Gannon said Murray is considered "day-to-day," via Alper. If he doesn't practice Friday, he would likely be sidelined for Sunday's road game against the Indianapolis Colts at 1 p.m. ET on Fox.

How would Kyler Murray not playing in Week 6 impact Cardinals?

The Cardinals would likely turn to journeyman QB Jacoby Brissett if Murray doesn't play. The 10-year veteran has played for six teams, including the New England

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