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Quick programming note: This newsletter will take a break for the Monday holiday, but we’ll be back in your inbox bright and early Tuesday. We’re lining up some great stories for next week, and don’t forget the STAT Summit is coming up in just five days.

The need-to-know this morning

Bristol Myers Squibb said it would acquire Orbital Therapeutics for $1.5 billion, picking up experimental in vivo CAR-T therapies that could be used to treat autoimmune diseases.

Boston’s biotech supremacy is being challenged

Boston has long been the undisputed capital of the world’s life sciences industry, but that may be changing, writes The Boston Globe’s Shirley Le

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