Colorado football is mired in a slump through the first six weeks of the 2025 college football season.

The Buffaloes (2-4, 0-3 Big 12) have lost two in a row and are seeking their first Big 12 Conference win of the season when they take on No. 21 Iowa State (5-1, 2-1) at 1:30 p.m. MT from Folsom Field in Boulder, Colorado , on Saturday, Oct. 11.

Colorado is coming off a 35-21 loss to TCU last week, with the defense struggling, allowing 24.8 points per game, which ranks 75th in the nation. The offense is averaging 25 points per game, which is 89th in the country.

Meanwhile, Iowa State is coming off a 38-30 loss to Cincinnati. Stream Colorado football vs. Iowa State live on Fubo (free trial)

Here's how to watch, including time, TV schedule, live streaming info and game odds:

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