Jarell Quansah has withdrawn from England's World Cup qualifier against Latvia with a knee injury.
The defender, 22, was unable to play any part in the Three Lions' friendly win against Wales at Wembley on Thursday.
Quansah is yet to make his senior debut, despite being called into five different England camps by Gareth Southgate, Lee Carsley and Thomas Tuchel.
A statement from the Three Lions read: "Jarell Quansah will miss England's forthcoming 2026 FIFA World Cup qualifier against Latvia through injury.
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"The Bayer Leverkusen defender returned to his club as a precaution foll