San Francisco 49ers at Tampa Bay Buccaneers odds, picks and predictions

Tampa Bay Buccaneers quarterback Baker Mayfield (6) passes the ball against the Seattle Seahawks during the second half at Lumen Field in Seattle, Washington.

The San Francisco 49ers (4-1) visit the Tampa Bay Buccaneers (4-1) Sunday at Raymond James Stadium in Tampa, Florida. Kickoff is scheduled for 4:25 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Buccaneers odds and make our expert NFL picks and predictions for the best bets.

San Francisco beat the LA Rams last week 26-23 in overtime, covering as an 8.5-road underdog as the Over (44) hit. QB Mac Jones threw for 342 yards and 2 TDs, with WR Kendrick Bourne the top target (10 receptions, 142 yards). The 49ers, who never trailed, rushed for just 74 yards, averaging 2.24 yards per carry in the upset win.

Tampa Bay outlasted the Seattle Seahawks 38-35 last week in an offensive shootout, covering as a 3.5-point road underdog with the Over (44.5) easily hitting. QB Baker Mayfield went 29-of-33 for 279 yards and 2 TDs with WR Emeka Egbuka having a monster day (7 catches, 163 yards, 1 TD). On the ground, RB Rachaad White punched in 2 TDs.

San Francisco leads the all-time series 21-7 and has won the last 4 meetings, including 23-20 last season.

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49ers at Buccaneers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:05 a.m. ET.

Moneyline (ML): 49ers +150 (bet $100 to win $150) | Buccaneers -180 (bet $180 to win $100)
Against the spread (ATS): 49ers +3.5 (-115) | Buccaneers -3.5 (-105)
Over/Under (O/U): 47.5 (O: -105 | U: -115)

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49ers at Buccaneers key injuries

49ers

DT Alfred Collins (knee) questionable
DT Kalia Davis (hand) questionable
DE Yetur Gross-Matos (knee, hamstring) out
WR Jauan Jennings (ankle, rib) questionable
QB Mac Jones (knee, oblique) questionable
WR Ricky Pearsall (knee) out
QB Brock Purdy (toe) out
CB Upton Stout (ankle) questionable
WR Jordan Watkins (calf) out

Buccaneers

WR Mike Evans (hamstring) out
WR Chris Godwin Jr. (fibula) out
RB Bucky Irving (foot, shoulder) out
S Christian Izien (quadricep) questionable
CB Zyon McCollum (thumb) out
CB Benjamin Morrison (hamstring) out

49ers at Buccaneers picks and predictions

Prediction

Buccaneers 27, 49ers 13

Moneyline

PASS.

There is minimal value on the Buccaneers (-180) to win against an injury-ridden 49ers (+150) squad.

Against the spread

BET BUCCANEERS -3.5 (-105).

Jones, who is questionable for Sunday's matchup, commanded the 49ers offense well in QB Brock Purdy's absence, but the Buccaneers, with home-field advantage, will prove to be more of a test for the backup QB.

The Buccaneers have covered in 3 of their 5 games this season, scoring at least 25 points in each of their last 3 games. The 49ers' offense is ranked 22nd in the NFL, while the Buccaneers rank 7th in the same metric.

In what will be a much different looking game due to numerous injuries on both sides, the Buccaneers, led by Mayfield, who ranks fourth in the NFL for passing yards and third with 10 TDs, should control this matchup.

Over/Under

BET UNDER 47.5 (-115).

With a plethora of star players sidelined ahead of Sunday, this game will have a slower pace than usual. Especially if Jones is out and QB Adrian Martinez gets the start; the 49ers offense will not be flowing in the way it should.

The 49ers have scored 21 or fewer points in 2 of their last 3 games and in 3 of their 5 games this season, while allowing 23 or fewer points in 4 of their 5 games.

The 49ers, who are still missing Evans and Godwin, have scored 25 or fewer points in 3 of their 5 game,s while their defense should see improvement against the Niners without Purdy under center.

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This article originally appeared on Sportsbook Wire: San Francisco 49ers at Tampa Bay Buccaneers odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect