New England Patriots quarterback Drake Maye (10) drops back to pass against the Buffalo Bills during the second half at Highmark Stadium in Orchard Park, New York.

The New England Patriots (3-2) visit the New Orleans Saints (1-4) Sunday in Week 6. Kickoff from Caesars Superdome in New Orleans, Louisiana, is at 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Patriots vs. Saints odds and make our expert NFL picks and predictions for the best bets.

The Patriots have won 2 straight games and are coming off a 23-20 road win over the previously unbeaten Buffalo Bills Sunday night as 8-point underdogs, with the Under (48.5) cashing. WR Stefon Diggs had 10 receptions for 146 yards, and K Andy Borregales hit a game-winning 52-yard field goal with 15 seconds left in the game.

The Saints picked up their first win of the season last week, beating the New York Giants 26-14 at home as 2.5-point favorites, with the Under (42) cashing. They came back from a 14-3 deficit. QB Spencer Rattler threw an 87-yard TD pass and the defense forced 5 turnovers, returning a fumble for a touchdown.

The Patriots lead the all-time series 10-6, but lost 34-0 at home in the last meeting in 2023.

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Patriots at Saints odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:58 a.m. ET.

  • Moneyline (ML): Patriots -190 (bet $190 to win $100) | Saints +155 (bet $100 to win $155)
  • Against the spread (ATS): Patriots -3.5 (-110) | Saints +3.5 (-110)
  • Over/Under (O/U): 46 (O: -110 | U: -110)

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Patriots at Saints key injuries

Patriots

  • CB Christian Gonzalez (hamstring) questionable
  • S Jaylinn Hawkins (hamstring) out
  • LB Anfernee Jennings (ankle) out
  • DE Keion White (elbow) out

Saints

  • RB Alvin Kamara (ankle) questionable
  • CB Isaac Yiadom (hamstring) out

Patriots at Saints picks and predictions

Prediction

Patriots 31, Saints 20

Moneyline

The Saints had 5 takeaways against the Giants, but in their previous 3 games, they allowed an average of 33.7 points per game. The Patriots put up 42 against the Carolina Panthers and 33 against the Miam Dolphins, so they have the offense to put up points against bad defenses.

Patriots QB Drake Maye had 3 straight games of 2 touchdown passes before playing Buffalo while last week's win is the only one Rattler has in his career.

You will get better value with the spread to take the Patriots.

PASS.

Against the spread

The Pats have covered the spread in all 3 of their wins this season. All 4 of the Saints' losses this season have been by more than 4 points.

BET PATRIOTS -3.5 (-110).

Over/Under

The Saints' 3 games before their win all had totals of 47 or more. Two of the Patriots' 3 wins had the Over hit.

BET OVER 46 (-110).

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This article originally appeared on Sportsbook Wire: New England Patriots at New Orleans Saints odds, picks and predictions

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

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