The Indianapolis Colts (4-1) look to stay hot at home as they host the Arizona Cardinals (2-3) in NFL Week 6. Daniel Jones and the Colts got back into the win column in Week 5 with a decisive 40-6 victory against the visiting Las Vegas Raiders. Meanwhile, Kyler Murray and the Cardinals suffered a second-half meltdown their last time out that resulted in a 22-21 loss to the Tennessee Titans. Cardinals quarterback is Kyler Murray (foot) isn't expected to play on Sunday.

Kickoff from Lucas Oil Stadium is set for 1 p.m. ET. Indianapolis is a 9.5-point favorite in the latest Cardinals vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 46.5. The Colts are -500 money line favorites (risk $500 to win $100), while the Cardinals are +374 underdogs. Before

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