The NFL appears to be back-loading its schedule with divisional games as, for the second week in a row, there are just two divisional matchups you can target in NFL betting and Week 6 NFL picks. Steelers vs. Browns (+6) is the only one on Sunday. Other Week 6 NFL spreads of at least 5 points include Rams vs. Ravens (+7), with Lamar Jackson ruled out, Colts vs. Cardinals (+8.5) with Kyler Murray (foot) expected to miss the game and Packers vs. Bengals (+14.5), in which Joe Flacco will make his Cincy debut under center.

The last of those matchups is the seventh game this year with an NFL line of more than 9 points, and heavy favorites are 3-3 ATS in those matchups. Thus, that NFL betting trend won't help much with your Week 6 NFL predictions, but there are others that could certainly assist

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