For those who have survived the minefield of the NFL's first five weeks, the NFL survivor pool options narrow even further. Besides the teams that have already been used, two more teams will have their bye this week with the Texans and Vikings. Among the SportsLine models biggest favorites to choose from this week are the Packers (-14.5). who are the biggest favorites of the 2025 NFL season versus a Cincinnati team slated to start Joe Flacco. Other large NFL spreads include Broncos (-7.5) vs. Jets, Rams (-7) vs. Ravens and Colts (-8.5) vs. Cardinals, who list Kyler Murray (foot) as questionable, though reports indicate he won't play.

Browns vs. Steelers (-6), Chargers vs. Dolphins (+3.5) and Titans vs. Raiders (-3.5) are some other games with a line more than a field goal to consider for

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