The 49ers lost another star defender to what appears to be a serious injury on Sunday against the Tampa Bay Buccaneers at Raymond James Stadium.

Star linebacker Fred Warner sustained a right ankle injury midway through the first quarter and the 49ers quickly ruled him out.

Warner was carted to the locker room with an air cast on his lower right leg.

Fred Warner had to be carted off the field after appearing to suffer a right leg injury

(via @NFLonCBS ) pic.twitter.com/lftZhabg9C — 49ers on NBCS (@NBCS49ers) October 12, 2025

49ers injury update: LB Fred Warner has an air cast on his right lower leg as he was taken to the locker room. — Matt Maiocco (@MaioccoNBCS) October 12, 2025

Warner appeared to have his right ankle rolled up on by teammate Ji'Ayir Brown.

If Warner's injur

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